Adipic Acid → HCID 86650872, compound

Participants

Reaction Steps

Dissolve (3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one (105 mg, 0.177 mmol) in methanol (0.8 mL) and ethyl acetate (2 mL). Add adipic acid (30 mg, 0.20 mmol) and evaporate at room temperature overnight to give a quantitative mass balance of (3R,5R)-3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one adipate (129 mg, 100%) as a candied solid: ES/MS m/z: 593.0 [M+H]+.

Provenance & Evidence