Diazald → HCID 178486597, compound

Participants

Reaction Steps

The compound was synthesized starting from KOH (10 eq in water), diazald (5 eq), ethylene glycol/Et2O (3/1 v/v), 1-(1H-benzo[d]imidazol-6-yl)-5-(2,3,5-trifluorophenyl)-3-hydroxy-4-phenyl-1H-pyrrol-2(5H)-one (0.230 g, 0.5 mmol, 1 eq) and MeOH/H2O (90/10 v/v); yield: 0.015 g (6.9%); MS m/z: 436.4 [M+H]+; 1H-NMR: (400 MHz, DMSO-D6) δ: 4.11 (s, 1H), 6.94 (s, 1H), 7.22-7.42 (m, 6H), 7.58-7.68 (m, 3H), 7.73-7.76 (m, 1H), 7.95 (s, 1H), 9.07 (s, 1H); HPLC (METHOD [A]): rt 15.38 min (82%)

Provenance & Evidence