Diazald → HCID 53380166, compound

Participants

Reaction Steps

The compound was synthesized starting from KOH (15 eq in water), diazald (8 eq), ethylene glycol/Et2O (1/4.2 v/v, 31 ml), 1-(1H-Benzo[d]imidazol-6-yl)-5-(2,3-difluorophenyl)-4-(4-fluorophenyl)-3-hydroxy-1H-pyrrol-2(5H)-one (0.5 g, 1.2 mmol, 1 eq) and MeOH (10 ml); yield: 0.160 g (60%); MS m/z: 436.1 [M+H]+; 1H-NMR: (400 MHz, DMSO-D6) δ: 10.5 (b, 1H), 7.88 (s, 1H), 7.72 (s, 1H), 7.59-7.56 (m, 1H), 7.26-7.00 (m, 4H), 6.91-6.86 (m, 3H), 6.38 (bs, 1H), 4.20 (s, 3H); HPLC (METHOD [A]): rt 15.20 min (97.35%)

Provenance & Evidence