1,1,2,2-Tetrafluoro-3-iodopropane → HCID 178431470, compound

HRID 1967631Notes

Reaction equation

HRID 1967631 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[C:13]([CH3:14])=[C:12]([OH:15])[C:11](=[O:16])[N:10]1[C:17]1[CH:32]=[CH:31][C:20]2[N:21](C(OC(C)(C)C)=O)[CH:22]=[N:23][C:19]=2[CH:18]=1.[F:33][CH:34]([F:40])[C:35]([F:39])([F:38])[CH2:36]I>>[F:38][C:35]([F:39])([CH:34]([F:40])[F:33])[CH2:36][O:15][C:12]1[C:11](=[O:16])[N:10]([C:17]2[CH:32]=[CH:31][C:20]3[NH:21][CH:22]=[N:23][C:19]=3[CH:18]=2)[CH:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[C:13]=1[CH3:14]

Participants

3

Reactant 2

HCID 5428611,1,2,2-Tetrafluoro-3-iodopropaneHCID 58433050HCID 58433050, compound

Product 1

HCID 178431470HCID 178431470, compound

Procedure

The compound was synthesized starting from tert-butyl 5-(2-(2,3-difluorophenyl)-4-hydroxy-3-methyl-5-oxo-2H-pyrrol-1(5H)-yl)-1H-benzo[d]imidazole-1-carboxylate (0.441 g, 1 mmol), 1,1,2,2-tetrafluoro-3-iodopropane (0.17 ml, 1.5 mmol) and P1-tBu (0.38 ml, 1.5 mmol) according to the method described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-e0f36e55ce4a4ca0b92e976f66916d88
Source dataset
uspto-grants-2013_04
Patent number
US08420828B2

Reaction notes

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