Acetic Acid → 5-Methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride

Participants

Reaction Conditions

Reaction Steps

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride (9.97 kg, 13.8 mol) was dispersed in acetic acid, and then anhydrous acetic acid (7.45 kg) was added thereto and the mixture was cooled to 5° C. Sulfuric acid (135 g) was slowly added thereto and the mixture was stirred for 1 hour. To the obtained clear solution, sodium acetate trihydrate (376 g) was added and dissolved at 0 to 5° C. And then water (96.6 kg) was added for 3 hours with maintaining 0 to 10° C. to produce solid. The produced solid was filtered and the title compound was obtained as a white solid (10.04 kg, yield 90.2%).

Provenance & Evidence