HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrobenzene → 3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrobenzene | HCID 7416 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Teriflunomide | HCID 54684141 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide | HCID 1472078 | — |
Reaction Steps
The present invention provides a process for preparation of Teriflunomide. Ethylacetoacetate (II) and 4-trifluoromethyl aniline (III) is refluxed in a solvent. The solvent is selected from aromatic hydrocarbon such as toluene, xylene, nitrobenzene, benzene and the like or mixtures thereof. The reaction mixture is refluxed for about 48 hours. The Reaction mixture is concentrated and purified by column chromatography to give pure 3-oxo-N-(4-trifluoromethylphenyl)butanamide (IV).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420856B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f77ce566c0664db383322554239cb5d5 |
| Source note | uspto-grants-2013_04 |