Diisopropylethylamine → 5-(3-chloro-benzoylamino)-N-[2,6-dimethyl-4-(1,2,2,2-tetra-fluoro-1-trifluoromethyl-ethyl)-phenyl]-2-phenoxy-benzamide

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Reaction Steps

5-(3-Chloro-benzoylamino)-2-phenoxy-benzoic acid (200 mg, 0.54 mmol) (see Example I2) was suspended in dichloromethane (2 ml), followed by the addition of bis(2-oxo-3-oxazolidinyl)phosphonic chloride “BOP-Cl” (208 mg, 0.81 mmol), diisopropyl-ethylamine “Hunigs base” (280 μl, 1.63 mmol) and 2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-aniline (158 mg, 0.54 mmol) (=4-heptafluoroisopropyl-2,6-dimethylaniline, prepared according to US 2002/198399). The reaction mixture was stirred for 18 hours at ambient temperature, followed by extraction with aqueous sodium bicarbonate (1N) and dichloromethane. The organic phase was washed successively with aqueous hydrochloric acid (2N) and aqueous sodium bicarbonate (1N), dried over sodium sulfate and concentrated. The residue was purified by preparative reverse phase chromatography to yield Compound No. A1 of Table A below (113 mg, 32% yield over three steps).

Provenance & Evidence