HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1967737Generated: October 31, 2026
Morpholine → N-[4-(2-Furyl)-5-morpholinothiazol-2-yl]-2-morpholinopyridine-4-carboxamide
https://huagongshe.com/reaction/1967737
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Chloro-N-[4-(2-furyl)-5-morpholinothiazol-2-yl]pyridine-4-carboxamide | HCID 23144123 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-[4-(2-Furyl)-5-morpholinothiazol-2-yl]-2-morpholinopyridine-4-carboxamide | HCID 23144302 | 27% |
Reaction Steps
Compound 39 (391 mg, 1.00 mmol) was dissolved in NMP (10 mL), morpholine (1.05 mL, 12.0 mmol) was added thereto, followed by stirring at 150° C. for 8 hours. The reaction mixture was purified through silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3) to afford the entitled Compound 40 (118 mg, 27%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420827B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-a9a0e848c7ef4fdd8c881e01b3368ee7 |
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| Source note | uspto-grants-2013_04 |
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