Fumaric Acid → HCID 23144718, compound

HRID 1967753Notes

Reaction equation

HRID 1967753 reaction equation
[NH2:1][C:2]1[S:3][C:4]([N:12]([CH2:14][CH2:15][O:16][CH3:17])[CH3:13])=[C:5]([C:7]2[O:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1.C(O)(=O)/C=[CH:20]/[C:21](O)=[O:22]>C(O)C>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[N:6]=[C:2]([NH:1][C:21](=[O:22])[CH3:20])[S:3][C:4]=1[N:12]([CH2:14][CH2:15][O:16][CH3:17])[CH3:13]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 23144559HCID 23144559, compound

Product 1

HCID 23144718HCID 23144718, compoundYield 21.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to that in Example 2, a free form of the entitled Compound was obtained from 2-amino-4-(2-furyl)-5-[N-(2-methoxyethyl)-N-methylamino]thiazole (160 mg, 0.63 mmol) obtained in Step 1 of Example 77, in place of Compound a. The resulting free form was dissolved in ethanol (5 mL), and fumaric acid (146 mg, 1.26 mmol) was added thereto, and the precipitated solid was collected by filtration to afford the entitled Compound 83 (39.8 mg, 18%).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-eeb6b8f765e84596a11ce5b0b5a94de8
Source dataset
uspto-grants-2013_04
Patent number
US08420827B2

Reaction notes

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