Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydroxide | HCID 961 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 23144771 | HCID 23144771 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23144495 | HCID 23144495 | 53.2% |
Reaction Steps
Compound 24 (840 mg, 2.45 mmol) was dissolved in THF (5 mL) and methanol (5 mL), and a 4 mol/L aqueous sodium of hydroxide solution (3 mL) was added thereto, followed by stirring at 60° C. for 2 hours. The reaction mixture was allowed to cool down, and neutralized with 2 mol/L hydrochloric acid added thereto. The precipitated solid was collected by filtration to afford the entitled Compound 95 (411 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08420827B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-eda1a65262084e49b7426d883309b390 |
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| Source note | uspto-grants-2013_04 |
|---|
