HCID 23144519, compound → HCID 23144780, compound

HRID 1967812Notes

Reaction equation

HRID 1967812 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[S:9][C:10]=1[C:11]([C:13]#[C:14][CH2:15][O:16][CH3:17])=[O:12].[H][H]>C(O)C.[C].[Pd]>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[S:9][C:10]=1[C:11]([CH2:13][CH2:14][CH2:15][O:16][CH3:17])=[O:12]

Participants

5

Reactant 2

HCID 23144519HCID 23144519, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23144780HCID 23144780, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Compound 414 (92.3 mg, 0.255 mmol) was dissolved in ethanol (5 mL), and 10% palladium-carbon (15.8 mg) was added thereto, followed by stirring in an atmosphere of hydrogen at room temperature for 1.5 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to afford the entitled Compound 415 (93.3 mg, 100%).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a20b03dd25e446a6b00401aa9b4aeb01
Source dataset
uspto-grants-2013_04
Patent number
US08420827B2

Reaction notes

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