4-Methylpyridine → Ethyl 2-furoate

HRID 1967877Notes

Reaction equation

CC1C=CN=CC=1.N1C=CC([C:14]2[CH:18]=[CH:17][O:16][C:15]=2[C:19]([O:21][CH2:22][CH3:23])=[O:20])=CC=1>>[O:16]1[CH:17]=[CH:18][CH:14]=[C:15]1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

Reactant 2

HCID 79634-Methylpyridine

HCID 23144513Ethyl 3-(4-pyridyl)furan-2-carboxylate

Product 1

HCID 11980Ethyl 2-furoate

Procedure

In a manner similar to that in Reference Example 13, by using 4-methylpyridine in place of 3,4-dimethylpyridine and using ethyl 3-(4-pyridyl)furan-2-carboxylate (133 mg, 0.612 mmol) obtained in Step 1, in place of ethyl furan-2-carboxylate, the entitled Compound ad (35.3 mg, 18%) was obtained.

Sources & evidence

ORD record: ord-d97205aad20e4a75a0e3e689ed28b603
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08420827B2

Reaction notes

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