HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1967985Generated: October 29, 2026
Potassium Carbonate → 1-Propyl-1H-imidazole-2-carbaldehyde
https://huagongshe.com/reaction/1967985
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-imidazole-2-carbaldehyde | HCID 24955 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Propyl-1H-imidazole-2-carbaldehyde | HCID 4777660 | 95.9% |
Reaction Steps
1H-imidazole-2-carbaldehyde (800 mg, 8.3 mmol), 1-iodopropane (1.7 g, 10 mmol) and potassium carbonate (1.4 g) were added in DMF (30 mL) and the mixture was heated to 50° C. overnight. Then the mixture was evaporated under reduced pressure, and extracted with ethyl acetate (100 mL×4). The combined organic layers were dried over anhydrous sodium sulfate, concentrated to give 1-propyl-1H-imidazole-2-carbaldehyde (1.1 g). LC-MS (ESI) m/z 139 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420650B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-4baeb15d9e3e468483932ecb9800d693 |
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| Source note | uspto-grants-2013_04 |
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