化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 5-(4-Bromophenyl)-3,4-dihydro-2h-pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | tert-Butyl 4-(4-bromophenyl)-4-oxobutylcarbamate | HCID 67151710 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 5-(4-Bromophenyl)-3,4-dihydro-2h-pyrrole | HCID 11424611 | 80.3% |
反応手順
tert-Butyl 4-(4-bromophenyl)-4-oxobutylcarbamate (3.42 g, 10 mmol) was stirred in TFA (10 mL) for 6 hrs. Then 50% NaOH solution was added to the mixture to make pH=13-14, the white precipitate was filtrated, washed with water and dried to give the title compound as a white solid (1.8 g, yield 80%). LC-MS (ESI) m/z: 224 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08420650B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-9f3f6415f3674fd4b770e2a857cdb0f8 |
| 出典メモ | uspto-grants-2013_04 |