HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric acid magnesium salt (1:1) → HCID 178519068, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 4-Amino-1,3-dihydro-2-benzofuran-1-one | HCID 12284649 | — |
| Reactant | Benzyl 2-(4-formylphenyl)pyrrolidine-1-carboxylate | HCID 86639042 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178519068 | HCID 178519068 | 39.7% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of benzyl 2-(4-formylphenyl)pyrrolidine-1-carboxylate (0.62 g, 2 mmol), 4-aminoisobenzofuran-1(3H)-one (0.298 g, 2 mmol), MgSO4 (2.4 g, 20 mmol) in CH3CN (20 mL) was refluxed at 120° C. for 4 days. After a hot filtration, the filtrate was concentrated in vacuo and the residue was purified by column chromatography (EtOAc:DCM:hexane=1:1:6) to give the title compound (0.35 g, yield 30%) as a white solid. LC-MS (ESI) m/z: 440 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420650B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0a8b079d7aba4a8db436057c4de8e299 |
| Source note | uspto-grants-2013_04 |