Sodium Hydroxide → HCID 67224845, compound

Participants

Reaction Steps

To an 8 mL scintillation vial equipped for stirring was added (R)-1-tert-butyl 3-methyl 4-((4-methyl-1-oxo-1-(pyrrolidin-1-yl)pentan-2-ylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate (160 mg, 0.339 mmol) under nitrogen. Aqueous NaOH (12N, 2 mL) and MeOH (1 mL) were added and the solution was stirred at 53° C. for 48 h. The reaction mixture was purified via preparative mass trigger LC-MS (AcCN/H2O, 5-90%). The fractions were collected, concentrated, and dried in vacuo to afford the title compound as yellow oil.

Provenance & Evidence