Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58293515 | HCID 58293515 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58293437 | HCID 58293437 | — |
Reaction Steps
To (2R,3S)-2-((1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)methylamino)-3-methylpentanoic acid was added THF (2 mL), followed by HATU (94 mg, 0.246 mmol), cyclopentanamine (70.0 mg, 0.822 mmol) and 4-methylmorpholine (83 mg, 0.822 mmol). The suspension was stirred at 43° C. for 36 h to afford the title compound, which was used in the next step without further purification. [M+H] calc'd for C26H38N4O5, 487; found, 487.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08420816B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-248fe8a4e610466da1babdb34f97cc22 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
