HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968237Generated: October 29, 2026
Cyclopentylamine → 1-tert-butyl 3-methyl 4-((1-(cyclopentylcarbamoyl)cyclopentylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate
https://huagongshe.com/reaction/1968237
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-((1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)methylamino)cyclopentanecarboxylic acid | HCID 58293428 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-tert-butyl 3-methyl 4-((1-(cyclopentylcarbamoyl)cyclopentylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate | HCID 58293471 | — |
Reaction Steps
To 1-((1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)methylamino)cyclopentanecarboxylic acid was added THF (2 mL), HATU (94 mg, 0.246 mmol), cyclopentanamine (70.0 mg, 0.822 mmol) and 4-methylmorpholine (83 mg, 0.822 mmol). The suspension was stirred at 43° C. for 36 h to afford the title compound, which was used in the next step without further purification. [M+H] calc'd for C26H36N4O5, 485; found, 485.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420816B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-f615cd5edd804f338d2546806c124892 |
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| Source note | uspto-grants-2013_04 |
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