Cyclobutylamine → 2-({(2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-6-(cyclobutylamino)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile

Participants

Reaction Steps

At RT, 80 mg (0.15 mmol) of 2-chloro-6-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile (Example 2A) and 26 μl (0.30 mmol) of cyclobutanamine were stirred in 1.5 ml of DMF overnight. The reaction mixture was then purified by preparative HPLC (acetonitrile/water). This gave 56 mg (65% of theory) of the target compound.

Provenance & Evidence