Hydrochloric Acid → 2-{4-(2-({(2-(4-Chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl N-(tert-butoxycarbonyl)-L-alanyl-L-leucinate hydrochloride

Participants

Reaction Steps

153 mg (0.18 mmol) of 2-{4-(2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl)phenoxy}ethyl N-(tert-butoxycarbonyl)-L-alanyl-L-leucinate were dissolved in 5 ml dichloromethane and 5 ml diethyl ether. 4.5 ml (17.8 mmol) of 4M hydrogen chloride in dioxane were added, and the mixture was stirred at room temperature for 3 h. The precipitate was filtered off, washed with diethyl ether and dried under high vacuum. This gave 68 mg (55. % of theory) of the desired target compound.

Provenance & Evidence