HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968377Generated: October 30, 2026
Phosphorus oxychloride → 2-(4-Bromophenyl)-1-phenyl-1H-benzo(d)imidazole
https://huagongshe.com/reaction/1968377
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Bromo-N-(2-(phenylamino)phenyl)benzamide | HCID 23094055 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-Bromophenyl)-1-phenyl-1H-benzo(d)imidazole | HCID 23094070 | 90.3% |
Reaction Steps
To a suspension of amide 1 (9.6 g, 26 mmol) in anhydrous 1,4-dioxane (100 mL) was added phosphorus oxychloride (POCl3) (9.2 mL, 100 mmol) slowly. The whole was then heated at 100° C. overnight. After cooling to RT, the mixture was poured into ice (200 g) with stirring. Filtration, followed by recrystallization in DCM/hexanes gave a pale grey solid 2 (8.2 g, in 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426040B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-ee43d749873f48fda7e03a40f3de9103 |
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| Source note | uspto-grants-2013_04 |
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