HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968405Generated: October 29, 2026
Sodium hydride → 2-Chloro-3-(5-(methylthio)-1,3,4-thiadiazol-2-ylthio)pyrazine
https://huagongshe.com/reaction/1968405
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Reactant | 5-methylsulfanyl-1,3,4-thiadiazole-2-thiol | HCID 178503620 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Chloro-3-(5-(methylthio)-1,3,4-thiadiazol-2-ylthio)pyrazine | HCID 23659517 | — |
Reaction Steps
The title compound was prepared according the procedure described in Example 1 by using 5-(methylthio)-1,3,4-thiadiazole-2-thiol (1.64 g, 10.00 mmol), NaH (60% dispersion in mineral oil, 445 mg, 11.00 mmol), and 2,3-dichloropyrazine (1.04 ml, 10.00 mmol) in DMF and benzene (12 ml, 1/1) by stirring at 50° C. for 20 hr and then at 110° C. for 4 hr under nitrogen atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426358B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-c321426676554518839d89780344a019 |
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| Source note | uspto-grants-2013_04 |
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