HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-[2-(4-Fluorophenyl)ethenyl]-3,5-dimethoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Reactant | (3,5-Dimethoxybenzyl)triphenylphosphonium bromide | HCID 10962038 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[2-(4-Fluorophenyl)ethenyl]-3,5-dimethoxybenzene | HCID 69901078 | — |
Reaction Steps
To a solution of (3,5-dimethoxybenzyl)triphenylphosphonium bromide (300 mg, 0.6 mM), 4-fluorobenzaldehyde (133 mg, 1.07 mM), catalytic amounts of 18 crown-6 in DCM was added 1.5 mL of 50% solution of NaOH. The reaction was stirred for 5 h and water was added. The water phase was extracted with ethyl acetate and the organic phase was combined. The crude product was purified through flash chromatography eluting with hexanes/ethyl acetate (98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426369B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-20a1444f9c434604ac7a57f065d89a43 |
| Source note | uspto-grants-2013_04 |