2-Methyl-1-(4-nitro-2-(trifluoromethyl)phenyl)-1H-imidazole → 4-(2-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)aniline

Participants

Reaction Steps

2-methyl-1-(4-nitro-2-trifluoromethyl-phenyl)-1H-imidazole (6.0 g, 22.1 mmol) is dissolved in ethanol (100 mL). After hydrogenation catalyzed by palladium (10 wt % on activated carbon, wet, Degussa type, 1 g) under 1 atm H2 balloon for overnight, the reaction mixture is filtered through a pad of celite and washed with ethanol. The combined filtrate and washings are concentrated to afford the title compound, which is used for next reaction without any further purification.

Provenance & Evidence