反应详情

1-Methyl-4-(4-nitro-1H-pyrazol-1-yl)piperidine (132 mg, 0.628 mmol) was dissolved in methanol (6 mL) and the flask was purged with N2. Pd/C (15 mg) was added and the flask was flushed with H2 and stirred under 1 atm H2 (balloon) for 3 hours. The reaction mixture was purged with N2, and filtered through a pad of Celite. The filtrate was concentrated to dryness, yielding 1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-amine.

1. customthe flask was purged with N2
2. additionPd/C (15 mg) was added
3. customthe flask was flushed with H2
4. customThe reaction mixture was purged with N2
5. filtrationfiltered through a pad of Celite
6. concentrationThe filtrate was concentrated to dryness