2,4-Dichloro-5-fluoropyrimidine → HCID 68780940, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-ethyl-1H-pyrazol-4-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4-dichloro-5-(trifluoromethyl)pyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (300 MHz, DMSO-D6) ppm 1.28-1.47 (m, 4H) 2.03 (d, J=8.82 Hz, 1H) 2.86 (d, J=13.2 Hz, 2H) 4.08 (q, J=7.1 Hz, 2H) 4.17 (t, J=6.8 Hz, 1H) 6.28 (dd, J=5.6, 2.88 Hz, 1H) 6.38 (s, 1H) 7.30 (s, 1H) 7.59 (s, 1H) 7.77 (d, J=22.4 Hz, 3H) 8.11 (s, 2H) 9.20-9.66 (m, 1H); MS (ESI(+)) m/e 408 (M+1)+.

Provenance & Evidence