2,4-Dichloro-5-fluoropyrimidine → HCID 68783568, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-ethyl-1H-pyrazol-4-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]heptane-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4-dichloro-5-(trifluoromethyl)pyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (400 MHz, DMSO-D6) ppm 1.15 (d, J=9.77 Hz, 1H) 1.22-1.33 (m, 2H) 1.37 (t, J=7.17 Hz, 3H) 1.45-1.68 (m, 5H) 1.89 (d, J=10.07 Hz, 1H) 2.22-2.33 (m, 1H) 2.62 (d, J=8.24 Hz, 1H) 4.07 (q, J=7.22 Hz, 2H) 4.24 (t, J=7.48 Hz, 1H) 6.69-6.93 (m, 1H) 7.26-7.43 (m, 1H) 7.78 (s, 1H) 8.06 (s, 1H) 9.09 (s, 1H); MS (ESI(+)) m/e 410 (M+H)+.

Provenance & Evidence