2,4,5-Trichloropyrimidine → HCID 68783820, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-cyclobutyl-1H-pyrazol-4-yl-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4,5-trichloropyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (300 MHz, DMSO-d6) ppm 1.42 (d, J=8.82 Hz, 1H) 1.71-1.83 (m, 2H) 2.11 (d, J=8.82 Hz, 1H) 2.29-2.46 (m, 4H) 2.77 (s, 1H) 2.88 (s, 1H) 4.14 (t, J=7.97 Hz, 1H) 4.65-4.81 (m, 1H) 6.28 (d, J=8.48 Hz, 1H) 6.38 (d, J=8.14 Hz, 1H) 7.24 (s, 1H) 7.53 (s, 1H) 7.68 (s, 1H) 7.79 (s, 2H) 7.89 (s, 1H) 9.09 (s, 1H); MS (ESI(+)) m/e 400 (M+H)+.

Provenance & Evidence