2,4-Dichloro-5-fluoropyrimidine → HCID 68779971, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-cyclobutyl-1H-pyrazol-4-yl-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4-dichloro-5-bromopyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (300 MHz, DMSO-d6) ppm 1.41 (d, J=8.82 Hz, 1H) 1.69-1.83 (m, 2H) 2.11 (d, J=8.82 Hz, 2H) 2.30-2.43 (m, 4H) 2.76 (s, 1H) 2.88 (s, 1H) 4.14 (t, J=7.46 Hz, 1H) 4.62-4.80 (m, 1H) 6.28 (d, J=5.76 Hz, 1H) 6.37 (d, J=5.09 Hz, 1H) 7.23 (s, 1H) 7.54 (s, 1H) 7.63 (s, 1H) 7.77 (s, 2H) 7.95 (s, 1H) 9.10 (s, 1H); MS (ESI(+)) m/e 445 (M+H)+.

Provenance & Evidence