2,4,5-Trichloropyrimidine → HCID 68782816, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-(2-phenylethyl)-1H-pyrazol-4-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4,5-trichloropyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (300 MHz, DMSO-d6) ppm 1.40 (d, J=8.72 Hz, 1H) 2.09 (d, J=8.72 Hz, 1H) 2.74 (s, 1H) 2.88 (s, 1H) 3.06 (t, J=7.34 Hz, 2H) 4.00-4.11 (m, 1H) 4.26 (t, J=7.34 Hz, 2H) 6.25 (d, J=5.55 Hz, 1H) 6.36 (d, J=5.55 Hz, 1H) 7.06-7.33 (m, 6H) 7.52 (s, 1H) 7.65 (s, 1H) 7.80 (s, 1H) 7.88 (s, 1H) 9.09 (s, 1H); MS (ESI(+)) m/e 450 (M+H)+.

Provenance & Evidence