2,4,5-Trichloropyrimidine → HCID 68782987, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-(3-methylbenzyl)-1H-pyrazol-4-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4,5-trichloropyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (400 MHz, DMSO-d6) ppm 1.40 (d, J=8.85 Hz, 1H) 2.10 (d, J=8.54 Hz, 1H) 2.27 (s, 3H) 2.52 (d, J=8.24 Hz, 1H) 2.75 (s, 1H) 2.87 (s, 1H) 4.05-4.19 (m, 1H) 5.19 (s, 2H) 6.15 (d, J=8.54 Hz, 1H) 6.28 (d, J=5.49 Hz, 1H) 6.86 (s, 1H) 6.99 (d, J=7.63 Hz, 1H) 7.03 (s, 1H) 7.08 (d, J=7.63 Hz, 1H) 7.20 (t, J=7.63 Hz, 1H) 7.44 (s, 1H) 7.54 (d, J=7.63 Hz, 1H) 7.56 (s, 1H) 7.74 (s, 1H) 7.83 (s, 1H) 8.71 (s, 1H); MS (ESI(+)) m/e 450 (M+H)+.

Provenance & Evidence