2,4,5-Trichloropyrimidine → HCID 68782987, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 1, substituting 1-(2-naphthylmethyl)-1H-pyrazol-4-amine for 1-methyl-1H-pyrazol-4-amine in Example 1B along with substitution of (+)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide for (+/−)-(1S,2S,3R,4R)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide and 2,4,5-trichloropyrimidine for 2,4-dichloro-5-fluoropyrimidine in Example 1A. 1H NMR (400 MHz, DMSO-d6) ppm 1.37 (d, J=8.85 Hz, 1H) 2.09 (d, J=8.85 Hz, 1H) 2.74 (s, 1H) 2.84 (s, 1H) 5.41 (s, 2H) 6.11 (d, J=8.85 Hz, 1H) 6.21 (d, J=8.54 Hz, 1H) 6.87 (s, 1H) 7.35 (dd, J=8.39, 1.68 Hz, 2H) 7.45-7.50 (m, 2H) 7.49-7.53 (m, 3H) 7.61 (s, 1H) 7.73 (s, 1H) 7.79-7.89 (m, 4H) 8.73 (s, 1H); MS (ESI(+)) m/e 486 (M+H)+.

Provenance & Evidence