HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968598Generated: October 29, 2026
Water → tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/1968598
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate | HCID 11709764 | — |
Reaction Steps
A suspension of ethyl-4-fluorobenzoate (16.8 g, 0.1 mol), tert-butyl piperazine-1-carboxylate (18.6 g, 0.1 mol) and potassium carbonate (20.7 g, 0.15 mol) in dimethylsulfoxide (100 mL) was stirred under N2 at 120° C. for 10 hours. The reaction mixture was cooled to room temperature and poured into water (1 L). The solid product was filtered off, washed with water and dried in vacuum oven overnight at 40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426422B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-72f12ca1c24449919249de9b6621eb31 |
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| Source note | uspto-grants-2013_04 |
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