HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → Methyl 2-(benzylamino)-4-fluorobenzoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | Benzaldehyde | HCID 240 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | Methyl 2-amino-4-fluorobenzoate | HCID 14075433 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Methyl 2-(benzylamino)-4-fluorobenzoate | HCID 43735197 | — |
Reaktionsschritte
Methyl 2-amino-4-fluorobenzoate (0.90 g), benzaldehyde (0.54 mL), sodium triacetoxyborohydride (1.58 g) and acetic acid (0.3 mL) in CH2Cl2 (20 mL) were stirred for 3 hours. The reaction was quenched with methanol, concentrated, and chromatographed on silica gel with 5% ethyl acetate/hexanes.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08426422B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-57a214675e1f4d38a25a7d03afe8db37 |
| Quellennotiz | uspto-grants-2013_04 |