HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 67145179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 5-Hydroxyindole | HCID 16054 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | HCID 67145179 | HCID 67145179 | — |
Reaction Steps
Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 5-hydroxyindole (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1M aqueous NaOH solution, and brine, and dried over Na2SO4. The solution was then filtered, concentrated, and the crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426422B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b2713ba36e1b4d4d82634841c2d3a922 |
| Source note | uspto-grants-2013_04 |