Formamide → HCID 178518022, compound

HRID 1968626Notes

Reaction equation

HRID 1968626 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4]([OH:5])=[N:14][CH:12]=[N:1]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 27249674-Fluoroanthranilic acid

Product 1

HCID 178518022HCID 178518022, compoundYield 78%

Procedure

2-Amino-4-fluorobenzoic acid (1.55 g, 10 mmol) in formamide (5 mL) was heated to 150° C. for 6 h. The mixture was cooled to room temperature with stirring. The precipitate was filtered out and washed with ethyl ether to give 1.3 g of 7-fluoroquinazolin-4-ol (78%).

Workup

  1. filtrationThe precipitate was filtered out
  2. washwashed with ethyl ether

Sources & evidence

ORD record
ord-4c84c1e617b24d718a9853e140553539
Source dataset
uspto-grants-2013_04
Patent number
US08426430B2

Reaction notes

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