Nitric Acid → HCID 178526403, compound

Participants

Reaction Conditions

Reaction Steps

7-Fluoroquinazolin-4-ol (1 g, 6.0 mmol) was dissolved in concentrated H2SO4 (3 mL) at 0° C. Concentrated HNO3 (3 mL) was added dropwise with stirring in 15 min. The mixture was heated to 100° C. for 3 h, and poured into ice-water with stirring after cooled to room temperature. The precipitate was filtered out and recrystallized with HOAc to give 0.60 g of 7-fluoro-6-nitroquinazolin-4-ol (38%).

Provenance & Evidence