HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → N-(3-ethynylphenyl)-7-fluoro-6-nitroquinazolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-7-fluoro-6-nitroquinazoline | HCID 10609358 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(3-ethynylphenyl)-7-fluoro-6-nitroquinazolin-4-amine | HCID 59142759 | 95% |
Reaction Steps
4-Chloro-7-fluoro-6-nitroquinazoline and 3-ethynylbenzenamine (234 mg, 2 mmol) was dissolved into isopropanol (5 mL) and refluxed for 3 h. After cooled to room temperature, the precipitate was filtered out and washed with water to give 0.59 g of N-(3-ethynylphenyl)-7-fluoro-6-nitroquinazolin-4-amine (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426430B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-7115e873948d4563878becb4441063ac |
| Source note | uspto-grants-2013_04 |