HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-7-nitroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178526462 | HCID 178526462 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-7-nitroquinazoline | HCID 830680 | 70% |
Reaction Steps
A mixture of 7-nitroquinazolin-4-ol (3.4 g, 17.79 mmol), thionyl chloride (20 mL), and DMF (0.5 mL) was refluxed for 48 h. After the mixture was cooled, excess thionyl chloride was removed by evaporation and the residue was azeotroped with toluene to afford 2.61 g (70%) of 4-chloro-7-nitroquinazoline as a yellowish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426430B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-fad8eed217c440ae93cef1ffebf094be |
| Source note | uspto-grants-2013_04 |