HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968640Generated: October 29, 2026
Benzenamine, 3-ethynyl- → N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine
https://huagongshe.com/reaction/1968640
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | N'-(2-cyano-4-nitrophenyl)-N,N-dimethylmethanimidamide | HCID 10900084 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine | HCID 16045443 | 93% |
Reaction Steps
A mixture of N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformamidine (1.00 g, 4.58 mmol) and 3-aminophenylacetylene (0.64 g, 5.49 mmol) in HOAc (15 mL) was stirred at 100° C. for 3 h and cooled to room temperature. The precipitate was filtered, washed with ether, and was dried in vacuo to give 1.23 g (93%) of N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426430B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-4562643278c1410c984b78e43112c2ef |
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| Source note | uspto-grants-2013_04 |
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