Nitric Acid → HCID 178526403, compound

Participants

Reaction Steps

7-Fluoroquinazolin-4-ol (1 g, 6.0 mmol) was dissolved in concentrated H2SO4 (3 mL) at 0° C. Concentrated HNO3 (3 mL) was added dropwise with stirring in 15 min. The mixture was stirred at 100° C. for 3 h and cooled to room temperature. The mixture was poured into ice-water with stirring. The precipitate was filtered and recrystallized in HOAc to give 0.60 g of 7-fluoro-6-nitroquinazolin-4-ol (38%).

Provenance & Evidence