HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-7-fluoro-6-nitroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178526403 | HCID 178526403 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-7-fluoro-6-nitroquinazoline | HCID 10609358 | — |
Reaction Steps
7-Fluoro-6-nitroquinazolin-4-ol (518 mg, 2 mmol) was dissolved into thionyl chloride (3 mL) containing 2 drops of DMF. The solution was refluxed for 3 h. The solvent was removed under reduced pressure to afford 4-chloro-7-fluoro-6-nitroquinazoline, which was used directly in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426430B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0c71aba21f6c4b4f9d55df9baae9515b |
| Source note | uspto-grants-2013_04 |