HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3-Trimethoxy-5-(prop-2-yn-1-yl)benzene → 5-[3-(3,4,5-Trimethoxyphenyl)prop-1-yn-1-yl]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3-Trimethoxy-5-(prop-2-yn-1-yl)benzene | HCID 15285621 | — |
| Reactant | 5-Iodopyrimidine-2,4-diamine | HCID 16110335 | — |
| Product | 5-[3-(3,4,5-Trimethoxyphenyl)prop-1-yn-1-yl]pyrimidine-2,4-diamine | HCID 16110323 | 80% |
Reaction Steps
2,4-Diamino-5-iodopyrimidine (236 mg) was allowed to react with 1,2,3-Trimethoxy-5-(prop-2-ynyl)benzene (412 mg) as per the general procedure to afford 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine as a white powder (251 mg, 80%): Rf=0.23 (9:1, CHCl3:MeOH); mp=decomposed above 190° C.; 1H NMR (DMSO-d6) δ 7.84 (s, 1H), 6.71 (s, 2H), 6.26 (s, 2H), 3.80 (s, 2H), 3.77 (s, 6H), 3.63 (s, 3H); 13C NMR (DMSO-d6) δ 163.8, 162.2, 158.7, 152.8, 136.0, 132.8, 105.2, 93.1, 90.1, 76.5, 60.1, 55.8, 25.6; Anal. (C16H18N4O3) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426432B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-789d715c1709481e99450eda2f5ba947 |
| Source note | uspto-grants-2013_04 |