HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Iodopyrimidine-2,4-diamine → 2,4-Diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Iodopyrimidine-2,4-diamine | HCID 16110335 | — |
| Reactant | 1,2,3-Trimethoxy-5-(1-methoxyprop-2-ynyl)benzene | HCID 16110340 | — |
| Product | 2,4-Diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine | HCID 16110329 | 90% |
Reaction Steps
2,4-Diamino-5-iodopyrimidine (236 mg) was allowed to react with 1,2,3-Trimethoxy-5-(1-methoxyprop-2-ynyl)benzene (473 mg) as per the general procedure to afford 2,4-Diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine as an orange powder (310 mg, 90%): Rf=0.31 (9:1, CHCl3:MeOH); mp=184-186° C.; 1H NMR (DMSO-d6) δ 7.91 (s, 1H), 6.82 (s, 2H), 6.40 (s, 2H), 5.30 (s, 1H), 3.79 (s, 6H), 3.66 (s, 3H), 3.35 (s, 3H); 13C NMR (DMSO-d6) δ 163.8, 162.3, 159.7, 152.8, 137.2, 134.8, 104.6, 92.6, 89.1, 81.9, 73.0, 60.0, 55.9, 55.4; Anal. (C17H20N4O4) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426432B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ed4fc5bb8bf8400cae3af3db922ab798 |
| Source note | uspto-grants-2013_04 |