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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968797Generated: October 30, 2026

HCID 58625150, compound → 3-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamine

https://huagongshe.com/reaction/1968797

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58625150HCID 58625150—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
Product3-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamineHCID 58625049—

Reaction Steps

A mixture of (3-propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-yl)-carbamic acid tert-butyl ester (0.00041 mol) in trifluoroacetic acid (1 mL) and DCM (10 mL) was stirred overnight at room temperature and the solvent was evaporated. The obtained residue was decomposed in diisopropyl ether/CH3CN, then the desired product was filtered off and dried to yield the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08426429B2
Source datasetuspto-grants-2013_04
ORD IDord-95a2bcf99dc24c3bb680479ac5844126
Source noteuspto-grants-2013_04