HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylamine → N-[3-(4-Nitro-3-propylaminomethyl-phenylsulfanyl)-phenyl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | N-[3-(3-Formyl-4-nitro-phenylsulfanyl)-phenyl]-benzenesulfonamide | HCID 58625048 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | N-[3-(4-Nitro-3-propylaminomethyl-phenylsulfanyl)-phenyl]-benzenesulfonamide | HCID 58625103 | — |
Reaction Steps
A mixture of N-[3-(3-formyl-4-nitro-phenylsulfanyl)-phenyl]-benzenesulfonamide (0.0027 mol), propylamine (0.003 mol) and NaBH(OAc)3 (0.0041 mol) in DCE (60 mL) was reacted overnight at room temperature. Then a 10% NaOH solution was added and the mixture was extracted with CH2Cl2. The extract was dried (MgSO4) and then purified by column chromatography over silica gel (eluent: 1:0 to 7:1 CH2Cl2:CH3OH). The product fractions were collected and the solvent was evaporated to yield the title compound as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426429B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-2d5ae19da45f41ea9ec3abfeef44a2e1 |
| Source note | uspto-grants-2013_04 |