HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968824Generated: November 2, 2026
Water → 3-(3-Dimethoxymethyl-4-nitro-phenoxy)phenylamine
https://huagongshe.com/reaction/1968824
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene | HCID 3570093 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3-(3-Dimethoxymethyl-4-nitro-phenoxy)phenylamine | HCID 58625052 | — |
Reaction Steps
K2CO3 (0.17 mol) and then 4-chloro-2-dimethoxymethyl-1-nitro-benzene (0.1 mol) was added to a solution of 3-amino-phenol (0.15 mol) in DMA (200 mL) and the reaction mixture was stirred at 130° C. for 24 hours. The mixture was poured out into water and extracted with diisopropyl ether. The extract was purified by column chromatography over silica gel (eluent: CH2Cl2:CH3OH 100:0 to 65:35). The product fractions were collected and the solvent was evaporated to yield the title compound as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426429B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-39b87a7da28242a5ab1b4fb564b80742 |
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| Source note | uspto-grants-2013_04 |
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