Tetrabutylammonium Fluoride → HCID 67436478, compound

Participants

Reaction Steps

To a solution of [(1S,2S)-1-({[4-(t-butyl-dimethyl-silanyloxy)-phenyl]-[(1R,2R)-2-(5-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-amino}-methyl)-2-methyl-butyl]-carbamic acid tert-butyl ester (190 mg) in THF (3 mL) was added TBAF in THF (1M, 1 mL) the resulting solution was stirred at rt for 2 h. The reaction mixture was diluted with EtOAc (30 mL) and washed with H2O (2×15 mL) and brine (15 mL). The EtOAc layer was dried (Na2SO4) and concentrated to give the titled compound (102 mg). MS (MH+ 472).

Provenance & Evidence