HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-{[Bis(benzyloxy)phosphoryl]oxy}-2,2-dimethylbutanoic acid | HCID 67235154 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate | HCID 86616512 | — |
Reaction Steps
To a solution of the product from Example 11B (0.211 g, 0.538 mmol) in dichloromethane (1.35 mL) at 0° C. were added DMF (4 μL) and a solution of oxalyl chloride in dichloromethane (2M, 0.538 mL) and the mixture was stirred for 45 minutes at 0° C. The solvent was evaporated under reduced pressure and the residue was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426388B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6f2b0ee761524fdeab48d2484955221f |
| Source note | uspto-grants-2013_04 |