反应详情

温度

40 °C

a 500-mL, one-necked, round-bottom flask equipped with a magnetic stirrer and stir bar was charged with 1,9-nonanediol (10.00 g, 62.3 mmol) in dimethyl sulfoxide (100 mL) and H2O (100 mL). To this was added slowly a solution of sodium hydroxide (5.0 g, 125.0 mmol) in H2O (10 mL) at room temperature. During addition of sodium hydroxide the reaction mixture generated heat and the temperature rose to ˜40° C. The mixture was stirred for one hour, and then dimethyl sulfate (16.52 g, 131 mmol) was added in four portions while maintaining the temperature of the reaction mixture at ˜40° C. The reaction mixture was stirred at room temperature overnight. Progress of the reaction was monitored by TLC (Note 1). TLC monitoring indicated that the reaction was 25% conversion. At this stage additional dimethyl sulfate (24.78 g, 196.44 mmol) was added and the resulting mixture was stirred at room temperature for an additional 24 h. After completion of the reaction, sodium hydroxide (10% solution in water) was added to the reaction mixture to adjust the pH of the solution to 11-13. The mixture was stirred at room temperature for 2 h and extracted with dichloromethane (3×100 mL). The combined organic layers were washed with H2O (200 mL), brine (150 mL), dried over anhydrous sodium sulfate (20 g), filtered and concentrated in vacuo to obtain a crude product (14 g). The crude product was purified by column chromatography using 250-400 mesh silica gel. A solvent gradient of ethyl acetate in hexanes (10-50%) was used to elute the product from the column. All fractions containing the desired pure product were combined and concentrated in vacuo to give pure 9-methoxy-1-nonanol (lot D-1027-155, 2.38 g, 21.9%). Completion of the reaction was monitored by thin layer chromatography (TLC) using a thin layer silica gel plate; eluent: 60% ethyl acetate in hexanes.

1. customa 500-mL, one-necked, round-bottom flask equipped with a magnetic stirrer
2. temperaturegenerated heat
3. customrose to ˜40° C
4. stirringThe mixture was stirred for one hour
5. stirringThe reaction mixture was stirred at room temperature overnight
6. stirringthe resulting mixture was stirred at room temperature for an additional 24 h
7. additionwas added to the reaction mixture
8. stirringThe mixture was stirred at room temperature for 2 h
9. extractionextracted with dichloromethane (3×100 mL)
10. washThe combined organic layers were washed with H2O (200 mL), brine (150 mL)
11. dry with materialdried over anhydrous sodium sulfate (20 g)
12. filtrationfiltered
13. concentrationconcentrated in vacuo
14. customto obtain a crude product (14 g)
15. customThe crude product was purified by column chromatography
16. washto elute the product from the column
17. additionAll fractions containing the desired pure product
18. concentrationconcentrated in vacuo